Understanding Chronic Inflammatory Response Syndrome (CIRS) Through a Functional Medicine Lens
by Dr Lisa Ballehr
Chronic Inflammatory Response Syndrome, or CIRS, is a complex and often misunderstood condition that can leave patients feeling chronically fatigued, mentally foggy, and plagued by a host of unexplained symptoms. Many individuals with CIRS have spent years searching for answers, only to be told their labs are “normal” or that their symptoms are psychosomatic. However, through the lens of functional medicine, we understand that CIRS is a real and measurable condition that demands a comprehensive and individualized approach.
What is CIRS?
CIRS is a systemic, multi-symptom illness that arises when the body is unable to properly regulate its immune response after exposure to biotoxins. These biotoxins can come from mold, Lyme disease, cyanobacteria, and other environmental triggers. For individuals with a genetic predisposition, their immune system struggles to clear these toxins, leading to persistent inflammation and a cascade of debilitating symptoms.
Symptoms of CIRS
CIRS can present with a wide range of symptoms, making it difficult to diagnose. Common symptoms include:
- Chronic fatigue and weakness
- Brain fog, difficulty concentrating, and memory issues
- Joint and muscle pain
- Headaches and migraines
- Shortness of breath
- Unexplained weight gain or loss
- Increased sensitivity to light, sound, or chemicals
- Mood disorders such as anxiety and depression
- Sleep disturbances
If this sounds familiar, you are not alone. Many CIRS patients have spent years being misdiagnosed or dismissed because conventional lab tests often fail to detect the underlying inflammatory markers driving their illness.
The Functional Medicine Approach to CIRS
Functional medicine seeks to uncover and address the root causes of illness rather than just managing symptoms. When it comes to treating CIRS, we take a step-by-step approach to help patients reclaim their health.
1. Identify and Remove the Source
The first step in treating CIRS is identifying and eliminating the exposure to biotoxins. This may involve environmental testing for mold in the home or workplace, addressing hidden infections such as Lyme disease, or removing other inflammatory triggers. Without addressing the root source, true healing cannot begin.
2. Reduce Inflammation and Support Detoxification
CIRS drives systemic inflammation, and reducing this inflammatory response is crucial. We use targeted nutraceuticals, anti-inflammatory dietary strategies, and lifestyle modifications to support the body’s natural detoxification pathways. Key interventions include:
- Binders: Cholestyramine or natural binders like activated charcoal and bentonite clay help bind and remove toxins from the body.
- Anti-inflammatory diet: A nutrient-dense, anti-inflammatory diet rich in healthy fats, fiber, and phytonutrients supports cellular healing and reduces oxidative stress.
- Liver support: Enhancing liver detoxification through supplements such as glutathione, milk thistle, and N-acetylcysteine (NAC).
3. Correct Hormonal and Immune Dysregulation
Chronic inflammation from CIRS can disrupt hormone balance, leading to adrenal dysfunction, thyroid abnormalities, and insulin resistance. By evaluating and restoring hormonal balance through targeted supplementation and lifestyle interventions, we help patients regain energy and metabolic function.
Additionally, immune dysfunction is a hallmark of CIRS. We use immune-modulating therapies, including low-dose naltrexone (LDN), adaptogenic herbs, and mitochondrial support, to help regulate immune responses and restore balance.
4. Rebuilding Neurological and Cognitive Function
Brain fog, memory impairment, and mood disorders are common in CIRS patients due to neuroinflammation. We focus on neuroprotective strategies, such as:
- Omega-3 fatty acids to support brain health
- Brain retraining programs such as DNRS (Dynamic Neural Retraining System)
- Stress reduction techniques, including meditation, breathwork, and HRV biofeedback
5. Ongoing Monitoring and Personalization
Every patient’s journey with CIRS is unique, requiring continuous monitoring and an individualized treatment approach. We use specialized lab testing to track progress, adjust protocols as needed, and ensure long-term recovery.
The Path to Healing
Recovering from CIRS is a journey, but with the right approach, healing is possible. At our practice, we combine the latest in functional medicine with evidence-based protocols to help patients regain vitality and reclaim their lives. If you suspect you may be dealing with CIRS, don’t lose hope—there are answers, and there is a path forward.
If you’re struggling with chronic symptoms and looking for a root-cause approach to healing, reach out to our team. You don’t have to navigate this alone—we’re here to guide you every step of the way.
Your First Step Toward Healing
If you’ve been struggling with fatigue, brain fog, anxiety, sleep issues, weight gain, or hormone imbalances, it’s time to look beyond the symptoms. The HPA axis is at the core of your stress response, and when it’s off balance, everything else follows.
Addressing HPA axis dysfunction is the first and most important step in restoring your energy, focus, and long-term health.
Let’s get you back to feeling your best.
Dr. Lisa Ballehr | Functional Medicine Physician | Mesa, AZ & Telemedicine Nationwide
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